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Decoding TNF receptor superfamily control of CD4+Foxp3+ Regulatory T cell-mediated tolerance: implications for the treatment of graft‑versus‑host disease

Abstract Allogeneic transplantation is a cornerstone treatment for hematologic malignancies and organ failure, yet its success is limited by graft-versus-host disease (GvHD) and allograft rejection. Conventional broad-spectrum immunosuppression compromises protective graft-versus-leukemia (GvL) effe...

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Principais autores: Chon-Kit Chou, Xinyang Wang, Ruiqi Yu, Hang Xu, Yibo Chen, Yang Yang, Zhonghao Chen, Chuangen Li, Tianzhen He, Xin Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-06-01
coleção:Cell Communication and Signaling
Assuntos:
Tregs
TNF Receptor Superfamily
TNFRSF
GvHD
Transplantation
Treg Expansion
Acesso em linha:https://doi.org/10.1186/s12964-026-02990-1
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