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Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor

Abstract The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and age-related diseases. Accordingly, senolytic drugs, whic...

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Principais autores: Shimpei Kawamoto, Haruki Horiguchi, Daisuke Torigoe, Masahiro Wakita, Koyu Ito, Sho Sugawara, Xiangyu Zhou, Takumi Mikawa, Jeong Hoon Park, Birte Kristin Jung, Yumiko Okumura, Hideka Miyagawa, Mikako Maruya, Nozomi Hori, Ken Uemura, Masataka Sugimoto, Michiyuki Matsuda, Naoki Mochizuki, Hiroshi Kondoh, Akiko Takahashi, Yuichi Oike, Eiji Hara
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2026-04-01
Serier:EMBO Reports
Fag:
Cellular Senescence
Senolysis
Senolytic Drug
Aging
Reproducibility
Online adgang:https://doi.org/10.1038/s44319-026-00740-5
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