Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor

Abstract The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and age-related diseases. Accordingly, senolytic drugs, whic...

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Detalhes bibliográficos

Principais autores:	Shimpei Kawamoto, Haruki Horiguchi, Daisuke Torigoe, Masahiro Wakita, Koyu Ito, Sho Sugawara, Xiangyu Zhou, Takumi Mikawa, Jeong Hoon Park, Birte Kristin Jung, Yumiko Okumura, Hideka Miyagawa, Mikako Maruya, Nozomi Hori, Ken Uemura, Masataka Sugimoto, Michiyuki Matsuda, Naoki Mochizuki, Hiroshi Kondoh, Akiko Takahashi, Yuichi Oike, Eiji Hara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-04-01
coleção:	EMBO Reports
Assuntos:	Cellular Senescence Senolysis Senolytic Drug Aging Reproducibility
Acesso em linha:	https://doi.org/10.1038/s44319-026-00740-5
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