Unraveling an enhancer-silencer regulatory element showing epistatic interaction with a variant that escaped genome-wide association studies

Summary: Regulation of gene expression has recently been complicated by identifying Epromoters, a subset of promoters with enhancer function. Here, we uncovered a dual cis-regulatory element, “ESpromoter,” exhibiting both enhancer and silencer function as a regulator of the nearby genes ATP2B4 and L...

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Ngā kaituhi matua:	Mathieu Adjemout, Samia Nisar, Amélie Escandell, Romain Torres, Magali Torres, Hong Thu Nguyen Huu, Alassane Thiam, Iris Manosalva, Babacar Mbengue, Alioune Dieye, Véronique Adoue, Salvatore Spicuglia, Pascal Rihet, Sandrine Marquet
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2025-07-01
Rangatū:	Cell Genomics
Ngā marau:	cis-regulatory elements enhancer-silencer dual function epistatic interaction functional variants severe malaria
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2666979X25001454
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!