Unraveling an enhancer-silencer regulatory element showing epistatic interaction with a variant that escaped genome-wide association studies

Summary: Regulation of gene expression has recently been complicated by identifying Epromoters, a subset of promoters with enhancer function. Here, we uncovered a dual cis-regulatory element, “ESpromoter,” exhibiting both enhancer and silencer function as a regulator of the nearby genes ATP2B4 and L...

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Principais autores:	Mathieu Adjemout, Samia Nisar, Amélie Escandell, Romain Torres, Magali Torres, Hong Thu Nguyen Huu, Alassane Thiam, Iris Manosalva, Babacar Mbengue, Alioune Dieye, Véronique Adoue, Salvatore Spicuglia, Pascal Rihet, Sandrine Marquet
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-07-01
סדרה:	Cell Genomics
נושאים:	cis-regulatory elements enhancer-silencer dual function epistatic interaction functional variants severe malaria
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2666979X25001454
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