Intracellular Salmonella delivery of an exogenous immunization antigen refocuses CD8 T cells against cancer cells, eliminates pancreatic tumors and forms antitumor immunity

IntroductionImmunotherapies have shown great promise, but are not effective for all tumors types and are effective in less than 3% of patients with pancreatic ductal adenocarcinomas (PDAC). To make an immune treatment that is effective for more cancer patients and those with PDAC specifically, we ge...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Vishnu Raman, Lars M. Howell, Shoshana M. K. Bloom, Christopher L. Hall, Victoria E. Wetherby, Lisa M. Minter, Ashish A. Kulkarni, Neil S. Forbes
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-10-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	bacterial therapy CD8 T cells intracellular antigen delivery refocus of vaccine immunity exogenous antigen recall antigen
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228532/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!