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Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.

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Hoofdauteurs: Vishnu Modur, Navneet Singh, Vakul Mohanty, Eunah Chung, Belal Muhammad, Kwangmin Choi, Xiaoting Chen, Kashish Chetal, Nancy Ratner, Nathan Salomonis, Matthew T. Weirauch, Susan Waltz, Gang Huang, Lisa Privette-Vinnedge, Joo-Seop Park, Edith M. Janssen, Kakajan Komurov
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2018-10-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-018-06810-0
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