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Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway

<p>Abstract</p> <p>Background</p> <p>The sustained virological response to interferon-alpha (IFN-α) in individuals infected with hepatitis C virus (HCV) genotype 1 is only 50%, but is about 80% in patients infected with genotype 2-6 viruses. The molecular mechanisms explaining the differences in IFN...

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Principais autores: Kousoulas Gus, Foster Timothy P, Garry Robert F, Datta Sibnarayan, Poat Bret, Chandra Partha K, Hazari Sidhartha, Wakita Takaji, Dash Srikanta
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2010-02-01
Serier:Virology Journal
Online adgang:http://www.virologyj.com/content/7/1/36
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