Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1

<p>Abstract</p> <p>The mechanisms underlying the Hepatitis C virus (HCV) resistance to interferon alpha (IFN-α) are not fully understood. We used IFN-α resistant HCV replicon cell lines and an infectious HCV cell culture system to elucidate the mechanisms of IFN-α resistance in cell culture. The IFN...

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Bibliografische Detailangaben

Hauptverfasser:	Lamaze Christophe, Koster Mario, Hauser Hansjorg, Wimley William C, Gunduz Feyza, Poat Bret, Samara¹ Maria, Chandra Partha K, Hazari Sidhartha, Datta Sibnarayan, Balart Luis A, Garry Robert F, Dash Srikanta
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2011-07-01
Schriftenreihe:	Virology Journal
Schlagworte:	Hepatitis C virus (HCV) Interferon alpha (IFN-α) Interferon alpha-receptor 1 (IFNAR1) Jak-Stat signaling nuclear translocation reverse transcription polymerase chain reaction (RT-PCR) HCV infection ER stress
Online-Zugang:	http://www.virologyj.com/content/8/1/351
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