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Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication

<p>Abstract</p> <p>Interferon alpha (IFN-α) binds to a cell surface receptor that activates the Jak-Stat signaling pathway. A critical component of this pathway is the translocation of interferon stimulated gene factor 3 (a complex of three proteins Stat1, Stat2 and IRF9) to the nucleus to activate...

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Principais autores: Balart Luis A, Alvarez Xavier, Gunduz Feyza, Chandra Partha K, Hazari Sidhartha, Poat Bret, Garry Robert F, Dash Srikanta
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2010-10-01
Serier:Virology Journal
Online adgang:http://www.virologyj.com/content/7/1/265
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