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Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

Sphingolipids (SLs) have been extensively investigated in biomedical research due to their role as bioactive molecules in cells. Here, we describe the effect of a SL analog, jaspine B (JB), a cyclic anhydrophytosphingosine found in marine sponges, on the gastric cancer cell line, HGC-27. JB induced...

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Autori principali: Francesca Cingolani, Fabio Simbari, Jose Luis Abad, Mireia Casasampere, Gemma Fabrias, Anthony H. Futerman, Josefina Casas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-08-01
Serie:Journal of Lipid Research
Soggetti:
sphingolipid
liquid chromatography-mass spectrometry
methuosis
autophagy
anticancer drug
Accesso online:http://www.sciencedirect.com/science/article/pii/S0022227520337780
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