Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis

Al-Yacoub et al. investigate the consequences of FBXO32 mutation on dilated cardiomyopathy. ER stress, abnormal CHOP activation and CHOP-induced apoptosis with no UPR effector activation are found to underlie the FBXO32 mutation induced cardiomyopathy, suggesting an alternative pathway that can be c...

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Bibliografische Detailangaben

Hauptverfasser:	Nadya Al-Yacoub, Dilek Colak, Salma Awad Mahmoud, Maya Hammonds, Kunhi Muhammed, Olfat Al-Harazi, Abdullah M. Assiri, Jehad Al-Buraiki, Waleed Al-Habeeb, Coralie Poizat
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2021-07-01
Schriftenreihe:	Communications Biology
Online-Zugang:	https://doi.org/10.1038/s42003-021-02391-9
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