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Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Abstract Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in various cancers, including brain tumors...

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Principais autores: Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-11-01
coleção:BMC Cancer
Assuntos:
Medulloblastoma
PRMT5
MYC protein
PRMT5 inhibitor
Acesso em linha:http://link.springer.com/article/10.1186/s12885-019-6291-z
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