Aberrant sphingosine-1-phosphate receptor 1 expression on activated naive B cells associated with disease activity and lupus nephritis in systemic lupus erythematosus

Abstract Background Systemic lupus erythematosus (SLE) is characterized by the immune system producing autoantibodies that target the body’s own cells and tissues, leading to inflammation and tissue damage. Sphingosine-1-phosphate receptor 1 (S1PR1) plays a crucial role in regulating immune cell tra...

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Principais autores:	Pachara Tianpothong, Piyawan Kochayoo, Thanitta Suangtamai, Sasicha Suksapan, Pongsakorn Thawornpan, Chaniya Leepiyasakulchai, Pintip Ngamjanyaporn, Prapaporn Pisitkun, Patchanee Chootong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
Colecção:	Arthritis Research & Therapy
Assuntos:	Sphingosine-1-phosphate receptor 1 Activated naive B cells Systemic lupus erythematosus
Acesso em linha:	https://doi.org/10.1186/s13075-026-03829-3
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