Lactylation of PFKP-K688 enhances glycolytic flux and confers cardioprotection in myocardial ischemia

Myocardial ischemia triggers metabolic reprogramming characterized by enhanced glycolysis and accumulation of lactic acid. However, the functional relevance of lactic acid-induced glycolysis-related protein lysine lactylation (Kla) remains poorly understood. In this study, utilizing both in vivo (LA...

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Үндсэн зохиолчид:	Cui Liu, Lujing Jiang, Panxia Wang, Yuehuai Hu, Yongjia Zheng, Lingzi Lu, Jing Lu, Yang Mao, Peiqing Liu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2026-03-01
Цуврал:	Frontiers in Pharmacology
Нөхцлүүд:	glycolysis lactic acid lactylation myocardial ischemia PFKP
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1717779/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!