Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier

Summary: Study investigators encountered a female Becker muscular dystrophy (BMD) carrier with advanced heart failure (HF) and identified a stop-gain variant in procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) as a potential second-hit variant. Isogenic induced pluripotent stem cells (iPSC...

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Principais autores:	Satoshi Kameda, MD, Shuichiro Higo, MD, PhD, Mikio Shiba, MD, PhD, Takumi Kondo, MD, Junjun Li, PhD, Li Liu, MD, PhD, Tomoka Tabata, MD, Hiroyuki Inoue, MD, Shota Okuno, MD, Shou Ogawa, MD, Yuki Kuramoto, MD, PhD, Hideki Yasutake, MD, PhD, Jong-Kook Lee, MD, PhD, Seiji Takashima, MD, PhD, Yoshihiko Ikeda, MD, PhD, Shungo Hikoso, MD, PhD, Shigeru Miyagawa, MD, PhD, Yasushi Sakata, MD, PhD
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2023-06-01
叢編:	JACC: Basic to Translational Science
主題:	Becker muscular dystrophy collagen DMD human induced pluripotent stem cell–derived cardiomyocytes PLOD3
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2452302X22004648
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