PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction

Background Cancer therapies inhibiting PI3Kα (phosphoinositide 3‐kinase‐α)–dependent growth factor signaling, including trastuzumab inhibition of HER2 (Human Epidermal Growth Factor Receptor 2), can cause adverse effects on the heart. Direct inhibition of PI3Kα is now in clinical trials, but the eff...

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Autori principali:	Brent A. McLean, Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Ratnadeep Basu, Faqi Wang, Saumya Shah, Bart Vanhaesebroeck, Gavin Y. Oudit
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2019-05-01
Serie:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Soggetti:	anthracycline heart atrophy PI3K remodeling right ventricle
Accesso online:	https://www.ahajournals.org/doi/10.1161/JAHA.118.010961
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