PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction

Background Cancer therapies inhibiting PI3Kα (phosphoinositide 3‐kinase‐α)–dependent growth factor signaling, including trastuzumab inhibition of HER2 (Human Epidermal Growth Factor Receptor 2), can cause adverse effects on the heart. Direct inhibition of PI3Kα is now in clinical trials, but the eff...

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Autores principales:	Brent A. McLean, Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Ratnadeep Basu, Faqi Wang, Saumya Shah, Bart Vanhaesebroeck, Gavin Y. Oudit
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2019-05-01
Colección:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Materias:	anthracycline heart atrophy PI3K remodeling right ventricle
Acceso en línea:	https://www.ahajournals.org/doi/10.1161/JAHA.118.010961
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