The potent activation of Ca2+-activated K+ current by NVP-AUY922 in the human pancreatic duct cell line (PANC-1) possibly independent of heat shock protein 90 inhibition

NVP-AUY922 (AUY) is a potent inhibitor of heat shock protein 90 (HSP90). Whether this compound can exert additional effects on membrane ion channels remains elusive. We investigated the effect of AUY on ion currents in human pancreatic duct epithelial cells (PDECs), including PANC-1 and MIA PaCa-2....

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Главные авторы:	Nai-Jung Chiang, Sheng-Nan Wu, Li-Tzong Chen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2015-04-01
Серии:	Journal of Pharmacological Sciences
Предметы:	AUY922 Ca2+-activated K+ current Large-conductance Ca2+-activated K+ channel Heat shock protein 90 Pancreatic duct epithelial cells
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S1347861315000420
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