Understanding the Hsp90 <i>N</i>-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922)

Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a molecular chaperone that facilitates protein maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 is highly dependent on adenosine triphosphate (ATP) binding to the <i>N</i>...

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Principais autores:	Ayanda M. Magwenyane, Ndumiso N. Mhlongo, Monsurat M. Lawal, Daniel G. Amoako, Anou M. Somboro, Sphelele C. Sosibo, Letitia Shunmugam, Rene B. Khan, Hezekiel M. Kumalo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-04-01
coleção:	Molecules
Assuntos:	Hsp90 protease <i>N</i>-terminal radicicol NVP-AUY922 density functional theory (DFT) molecular dynamics (MD)
Acesso em linha:	https://www.mdpi.com/1420-3049/25/8/1785
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