IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.

Adenosine inhalation produces immediate bronchoconstriction in asthmatics but not in normal subjects. The bronchospastic effect of adenosine is largely mediated through adenosine-induced mast cell activation, the mechanism of which is poorly understood due to limitations in culturing human primary m...

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Hlavní autoři:	Xiaoyang Hua, Kelly D Chason, Janki Y Patel, Warren C Naselsky, Stephen L Tilley
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2011-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3180290?pdf=render
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