HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease
IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine. This neurologic condition is characterized by a severe and progressive de...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2023-07-01
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| Seri Bilgileri: | Frontiers in Molecular Neuroscience |
| Konular: | |
| Online Erişim: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1231659/full |
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