HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

IntroductionIn Krabbe disease (KD), mutations in β-galactosylceramidase (GALC), a lysosomal enzyme responsible for the catabolism of galactolipids, leads to the accumulation of its substrates galactocerebroside and psychosine. This neurologic condition is characterized by a severe and progressive de...

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Autors principals:	Sandra O. Braz, Marlene M. Morgado, Marta I. Pereira, Ana C. Monteiro, Olga Golonzhka, Matthew Jarpe, Pedro Brites, Monica M. Sousa, Joana Nogueira-Rodrigues
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-07-01
Col·lecció:	Frontiers in Molecular Neuroscience
Matèries:	axonal transport HDAC6 Krabbe disease leukodystrophy microtubule stability tubulin acetylation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1231659/full
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