DNER drives glycolytic reprogramming in renal cell carcinoma by activating the JAK2/STAT3 signaling pathway

IntroductionClear cell renal cell carcinoma (ccRCC) remains a clinically challenging malignancy due to late diagnosis and limited therapeutic options. This study aimed to investigate the role of DNER in the progression of ccRCC.MethodsBioinformatic analyses were integrated with experimental validati...

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Principais autores:	Anrui Li, Jing-wen Xu, Jian-hua Qin, Qi Yuan, Lichen Teng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
Colecção:	Frontiers in Immunology
Assuntos:	clear cell renal cell carcinoma DNER glycolysis metabolic reprogramming olaparib tumor microenvironment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1799104/full
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