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Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3

Abstract Acute lung injury (ALI) is characterized by an unregulated inflammatory reaction, often leading to severe morbidity and ultimately death. Excessive inflammation caused by M1 macrophage polarization and pyroptosis has been revealed to have a critical role in ALI. Recent study suggests that g...

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Autori principali: Guiyin Zhu, Haiyang Yu, Tian Peng, Kun Yang, Xue Xu, Wen Gu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-07-01
Serie:Respiratory Research
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Accesso online:https://doi.org/10.1186/s12931-024-02926-8
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