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Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a dismal prognosis, and despite significant advances in our understanding of its genetic drivers, like KRAS, TP53, CDKN2A, and SMAD4, effective therapies remain limited. Here, we identified a new therapeutic ta...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To, Yangchao Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2023-08-01
Schriftenreihe:Biomarker Research
Schlagworte:
Pancreatic ductal adenocarcinoma
Therapeutic target
Oncogene
NMDA receptor
GRIN2D
Online-Zugang:https://doi.org/10.1186/s40364-023-00514-4
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