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Epigenetic modulation enhances immunotherapy for pancreatic ductal adenocarcinoma

Abstract Objectives Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a poor prognosis. PDAC has poor response to immunotherapy because of its unique tumour microenvironment (TME). In an attempt to stimulate immunologically silent pancreatic cancer, we investigated the role of ep...

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Principais autores: Yan Li, Young K Hong, Xingtong Wang, Harshul Pandit, Qianqian Zheng, Youxi Yu, Xiaoju Shi, Yujia Chen, Min Tan, Zachary Pulliam, Neal Bhutiani, Andrew Lin, Jeremy Badach, Ping Zhang, Robert CG Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2022-01-01
coleção:Clinical & Translational Immunology
Assuntos:
checkpoint inhibitors
epigenetic modulation
immunotherapy
pancreatic ductal adenocarcinoma (PDAC)
Acesso em linha:https://doi.org/10.1002/cti2.1430
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