Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold

β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery of compounds 27f and 39f, which exhibited potent inh...

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Autors principals:	Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2023-12-01
Col·lecció:	Journal of Enzyme Inhibition and Medicinal Chemistry
Matèries:	β-Elemene Histone deacetylase inhibitor Hybrid drugs Lymphoma
Accés en línia:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2195991
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