The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links
Abstract Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the development of colorectal cancer. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links. While cells have evolved multip...
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| Principais autores: | , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Portfolio
2025-11-01
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| סדרה: | Nature Communications |
| גישה מקוונת: | https://doi.org/10.1038/s41467-025-65606-1 |
| תגים: |
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