The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links

Abstract Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the development of colorectal cancer. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links. While cells have evolved multip...

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Bibliografiske detaljer

Principais autores:	Maria Altshuller, Xu He, Elliot J. MacKrell, Kevin M. Wernke, Yougant Airan, Joel W. H. Wong, Selene Sellés-Baiget, Ting-Yu Wang, Tsui-Fen Chou, Julien P. Duxin, Emily P. Balskus, Seth B. Herzon, Daniel R. Semlow
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-11-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-65606-1
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