Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications

Cuproptosis is a regulated form of cell death triggered by copper overload and dependent on mitochondrial metabolism, particularly through FDX1-mediated protein lipoylation and TCA cycle disruption. Recent studies have revealed that epigenetic mechanisms, including DNA methylation, histone modificat...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Xin Zhang, Yixiao Yuan, Lin Tang, Juan Wang, Lincan Duan, Xiulin Jiang, Jia Zhang
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2026-06-01
سلاسل:	Frontiers in Cell and Developmental Biology
الموضوعات:	cancer therapeutics copper metabolism cuproptosis FDX1 metal homeostasis mitochondrial cell death
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1814142/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!