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CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

Abstract The TMPRSS2 cell surface protease is used by a broad range of respiratory viruses to facilitate entry into target cells. Together with ACE2, TMPRSS2 represents a key factor for SARS-CoV-2 infection, as TMPRSS2 mediates cleavage of viral spike protein, enabling direct fusion of the viral env...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ildar Gabaev, Alexandra Rowland, Emilija Jovanovic, Christian M. Gawden-Bone, Thomas W. M. Crozier, Ana Teixeira-Silva, Edward J. D. Greenwood, Pehuén Pereyra Gerber, Niek Wit, James A. Nathan, Nicholas J. Matheson, Paul J. Lehner
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-04-01
Schriftenreihe:Scientific Reports
Schlagworte:
Transmembrane serine proteases
Coronavirus entry factors
CRISPR-Cas9 screen
Colon epithelial cells
Hypoxic regulation of surface proteins
Online-Zugang:https://doi.org/10.1038/s41598-025-95644-0
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