Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activa...

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Principais autores:	Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2026-03-01
Serija:	Experimental Physiology
Teme:	fragile X syndrome HCN channels intrinsic properties mediodorsal thalamus prefrontal cortex spike timing
Online dostop:	https://doi.org/10.1113/EP092894
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