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Tailored biomimetic nanoreactor improves glioma chemodynamic treatment via triple glutathione depletion and prompt acidity elevation

Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous H2O2 into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy...

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Principais autores: Ya Wen, Qiansai Qiu, Feng Feng, Yujuan Zhu, Jianquan Zhang, Zesheng Sun, Tuodi Zhang, Wei Shi, Jinlong Shi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-02-01
coleção:Materials Today Bio
Assuntos:
Biomimetic nanoreactor
GSH exhaustion
Acidity elevation
Chemodynamic therapy
Glioma
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2590006425000055
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