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CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion

Abstract Background Bladder cancer (BC) can be characterized clinically as either non-muscle-invasive (NMIBC) or muscle-invasive (MIBC). While NMIBC generally has a favorable prognosis, MIBC is characterized by high morbidity and mortality. Understanding the molecular determinants of tumor invasion...

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Principais autores: Junnan Liu, Wencheng Jiang, Xue Wang, Anca Azoitei, Hengchuan Liu, Gregoire Najjar, Kuangzheng Liu, Michael Karl Melzer, Stephan Stilgenbauer, Mohamed Elati, Martin D. Burkhalter, Melanie Philipp, Felix Wezel, Friedemann Zengerling, Christian Bolenz, Cagatay Günes
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-05-01
coleção:Cellular & Molecular Biology Letters
Assuntos:
Bladder cancer
NMIBC
MIBC
Invasion
Metastasis
Ex vivo tissue model
Acesso em linha:https://doi.org/10.1186/s11658-026-00936-6
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