CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion

Abstract Background Bladder cancer (BC) can be characterized clinically as either non-muscle-invasive (NMIBC) or muscle-invasive (MIBC). While NMIBC generally has a favorable prognosis, MIBC is characterized by high morbidity and mortality. Understanding the molecular determinants of tumor invasion...

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Bibliografski detalji

Glavni autori:	Junnan Liu, Wencheng Jiang, Xue Wang, Anca Azoitei, Hengchuan Liu, Gregoire Najjar, Kuangzheng Liu, Michael Karl Melzer, Stephan Stilgenbauer, Mohamed Elati, Martin D. Burkhalter, Melanie Philipp, Felix Wezel, Friedemann Zengerling, Christian Bolenz, Cagatay Günes
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-05-01
Serija:	Cellular & Molecular Biology Letters
Teme:	Bladder cancer NMIBC MIBC Invasion Metastasis Ex vivo tissue model
Online pristup:	https://doi.org/10.1186/s11658-026-00936-6
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