Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance

Abstract Background Kanamycin, an aminoglycoside, is an effective broad-spectrum antimicrobial agent against bacterial infections. However, the clinical efficacy of aminoglycosides has been overshadowed by the emergence of resistance mechanisms involving enzyme-mediated covalent modifications. Amino...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Jiahui Wang, Minghui Yu, Mingzhen Zhang, Zhihui Meng, Peitong Yang, Xingyu Cui, Ziqian Yu, Yongan Wang, Gongli Zong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	BMC Microbiology
Assuntos:	Exiguobacterium sp. Aminoglycoside nucleotidyltransferases Kanamycin ANT inhibitor Bicuculline
Acesso em linha:	https://doi.org/10.1186/s12866-026-04746-w
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!