Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance

Abstract Background Kanamycin, an aminoglycoside, is an effective broad-spectrum antimicrobial agent against bacterial infections. However, the clinical efficacy of aminoglycosides has been overshadowed by the emergence of resistance mechanisms involving enzyme-mediated covalent modifications. Amino...

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Bibliografski detalji

Glavni autori:	Jiahui Wang, Minghui Yu, Mingzhen Zhang, Zhihui Meng, Peitong Yang, Xingyu Cui, Ziqian Yu, Yongan Wang, Gongli Zong
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-02-01
Serija:	BMC Microbiology
Teme:	Exiguobacterium sp. Aminoglycoside nucleotidyltransferases Kanamycin ANT inhibitor Bicuculline
Online pristup:	https://doi.org/10.1186/s12866-026-04746-w
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