Virus-derived serpin reduces immuno-coagulopathic damage in murine colitis by targeting the urokinase-type plasminogen activator receptor (uPAR) and complement

Abstract A virus-derived serpin, Serp-1, has proven efficacy in treating inflammatory and coagulation disorders in preclinical and clinical studies. Serp-1 evolved over millions of years to block host immune responses, targeting serine proteases in immune and coagulation pathways. Treatment with PEG...

Full description

Bibliographic Details

Main Authors:	Alexandra R. Lucas, Henna Monder, Junior Enow, Cheyanne Woodrow, Laurel Spaccarelli, Aman Garg, Jessika Schlievert, Nora Elmadbouly, Aashika Dupati, Emily Aliskevich, Rohan Saju, Jacqueline Kilbourne, Kenneth Lowe, Mostafa Hamada, Aubrey Pinteric, Isabela R. Zanetti, Ritvik Srivant Satyanarayanan, Savanah Gisriel, Esther Borges Florsheim, Masmudur Rahman, James Irving, Grant McFadden, Wei Kong, Liqiang Zhang
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2025-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-025-32690-8
Tags:	Add Tag No Tags, Be the first to tag this record!