Virus-derived serpin reduces immuno-coagulopathic damage in murine colitis by targeting the urokinase-type plasminogen activator receptor (uPAR) and complement

Abstract A virus-derived serpin, Serp-1, has proven efficacy in treating inflammatory and coagulation disorders in preclinical and clinical studies. Serp-1 evolved over millions of years to block host immune responses, targeting serine proteases in immune and coagulation pathways. Treatment with PEG...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Alexandra R. Lucas, Henna Monder, Junior Enow, Cheyanne Woodrow, Laurel Spaccarelli, Aman Garg, Jessika Schlievert, Nora Elmadbouly, Aashika Dupati, Emily Aliskevich, Rohan Saju, Jacqueline Kilbourne, Kenneth Lowe, Mostafa Hamada, Aubrey Pinteric, Isabela R. Zanetti, Ritvik Srivant Satyanarayanan, Savanah Gisriel, Esther Borges Florsheim, Masmudur Rahman, James Irving, Grant McFadden, Wei Kong, Liqiang Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-12-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-025-32690-8
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!