Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

Summary: Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers K...

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Bibliografiske detaljer

Principais autores:	Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2023-08-01
Serier:	iScience
Fag:	Natural sciences Biological sciences Biochemistry Systems biology Cancer systems biology
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2589004223014451
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