Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Abstract Background Transferrin receptor 1 (TfR1) mediated brain delivery of antibodies could become important for increasing the efficacy of emerging immunotherapies in Alzheimer's disease (AD). However, age, dose, binding to TfR1 on blood cells, and pathology could influence the TfR1-mediated tran...
Gardado en:
| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2023-05-01
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| Series: | Fluids and Barriers of the CNS |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1186/s12987-023-00435-2 |
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