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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Recent development of amyloid-β (Aβ)-targeted immunotherapies for Alzheimer’s disease (AD) have highlighted the need for accurate diagnostic methods. Antibody-based positron emission tomography (PET) ligands are well suited for this purpose as they can be directed toward the same target as the thera...

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Bibliografische gegevens
Hoofdauteurs: Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis Group 2024-12-01
Reeks:mAbs
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Online toegang:https://www.tandfonline.com/doi/10.1080/19420862.2024.2339337
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