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Recipient‐derived macrophages mediate acute cardiac allograft rejection via GSDMD‐induced pyroptosis mechanism

Abstract Objective To determine whether macrophage gasdermin D (GSDMD)‐dependent pyroptosis drives acute cardiac allograft rejection and whether targeting GSDMD improves graft survival. Methods GSDMD activation was assessed by immunoblotting. Graft survival wasanalysed in global and macrophage‐speci...

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Principais autores: Bixian Luo, Zelai Wu, Chengyu Hu, Anqi Ni, Jun He, Hongming Liu, Weixun Xie, Fuping Li, Weihua Gong
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-07-01
Serier:Clinical and Translational Medicine
Fag:
GSDMD
heart transplantation
macrophages
pyroptosis
Online adgang:https://doi.org/10.1002/ctm2.70729
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