Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells

Abstract Background Glioblastoma (GBM) is the most common malignant brain tumor with a dismal prognosis (< 7% 5-year survival) under current first-line treatment. While inducing programmed cell death (PCD) is a promising antitumor strategy, its effectiveness in GBM remains controversial. Ferroptosis...

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Библиографические подробности

Главные авторы:	Maorong Zhu, Yuxin Wu, Huihui Ou, Xiao Liu, Yawen Wang, Xiaolin Liu, Cheng Zou, Guangzhao Yang, Mingrui Du, Duo Yu, Dan Zheng, Lei He, Kuo Zhang, Wangqian Zhang, Shuning Wang, Haozhe Qin, Qiang Hao, Yalong He, Wei Lin, Yingqi Zhang, Jintao Gu, Meng Li, Weidong Qin, Zhengcong Cao
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-01-01
Серии:	Journal of Nanobiotechnology
Предметы:	CRISPR screens Glioblastoma TRIM25 VDAC2 Gene editing Ferroptosis
Online-ссылка:	https://doi.org/10.1186/s12951-025-03908-8
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