Exosome-transmitted circCABIN1 promotes temozolomide resistance in glioblastoma via sustaining ErbB downstream signaling

Abstract Although temozolomide (TMZ) provides significant clinical benefit for glioblastoma (GBM), responses are limited by the emergence of acquired resistance. Here, we demonstrate that exosomal circCABIN1 secreted from TMZ-resistant cells was packaged into exosomes and then disseminated TMZ resis...

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Hlavní autoři:	Xiao Liu, Qingdong Guo, Guangxun Gao, Zhengcong Cao, Zhihao Guan, Bo Jia, Weizhong Wang, Kuo Zhang, Wangqian Zhang, Shuning Wang, Weina Li, Qiang Hao, Yingqi Zhang, Meng Li, Wei Zhang, Jintao Gu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-02-01
Edice:	Journal of Nanobiotechnology
Témata:	Glioblastoma Temozolomide resistance Exosome circCABIN1 Stemness
On-line přístup:	https://doi.org/10.1186/s12951-023-01801-w
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