Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

Abstract Angiopoietin‐1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. We hypothesized that systemic therapy with Vasculotide (VT)—a purported Ang1 mimetic, Tie2 agonist—can reduce the extravas...

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Bibliografische Detailangaben

Hauptverfasser:	Florence TH Wu, Christina R Lee, Elena Bogdanovic, Aaron Prodeus, Jean Gariépy, Robert S Kerbel
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2015-04-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	angiopoietin metastasis Tie2 tumor cell extravasation vascular permeability
Online-Zugang:	https://doi.org/10.15252/emmm.201404193
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