Erythropoiesis–inosine metabolic axis failure underlying retinal neurodegeneration in glaucoma: novel diagnoses and therapies

Abstract Glaucoma, long considered an ocular-limited, age-dependent and hypoxia-driven neurodegeneration, is here reframed as a systemic erythroid–inosine axis failure that originates in the bone marrow yet culminates in retinal ganglion cell (RGC) death. By mining UK Biobank datasets (n = 127,028)...

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Autors principals:	Yuyu Chou, Wuping Liu, Yanxiu Li, Changhan Chen, Cheng Luo, Shiping Shen, Piaoyu Dai, Lemeng Feng, Wenhao Xiao, Yiyan Wang, Juncheng Wang, Linlin Wan, Zhiyu Yang, Tingting Xie, Yujin Zhang, Rodney E. Kellems, Weitao Song, Xiaobo Xia, Yang Xia
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2026-02-01
Col·lecció:	Experimental and Molecular Medicine
Accés en línia:	https://doi.org/10.1038/s12276-026-01654-x
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