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TMPRSS2 is dispensable for lethal SARS-CoV-2 BA.5 infection in humanized hACE2 golden hamsters

Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV-2) can specifically bind to the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell surface via the corresponding spike (S) protein, facilitating the entry of the virus. ACE2 is highly expressed in alveolar type II cells,...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Bowen Wang, Jinwei Zhang, Yuhan Li, Haodong Wang, Mei Dong, Qiu Chen, Aimin Shi, Aihua Zhang, Wentao Zeng, Xuefeng Wang, Jianmin Li
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2026-01-01
Rangatū:European Journal of Medical Research
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s40001-025-03785-9
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