Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

Objective: Exploitation of protective metabolic pathways within injured myocardium still remains an unclarified therapeutic target in heart disease. Moreover, while the roles of altered fatty acid and glucose metabolism in the failing heart have been explored, the influence of highly dynamic and nut...

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Autors principals:	Rebecca C. Schugar, Ashley R. Moll, D. André d’Avignon, Carla J. Weinheimer, Attila Kovacs, Peter A. Crawford
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2014-10-01
Col·lecció:	Molecular Metabolism
Matèries:	Myocardial ketone body metabolism Nuclear magnetic resonance (NMR) measurement of substrate metabolism Ventricular remodeling Oxidative stress Mitochondrial metabolism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2212877814001367
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